2026.02.02
Facing a Time Crunch in Experiments? This Pre-Coated Plate Keeps Hepatocyte Cultures "Sticking" with Confidence!
Type I Collagen (Type I Rat Tail Collagen) is the primary structural protein widely distributed across various tissues and a key component of the extracellular matrix (ECM). In cell culture, it significantly enhances primary hepatocyte attachment, spreading, and differentiation, thereby improving cell survival rates in vitro.
Among them, Rat Tail Type I Collagen, extracted from rat tail tendons, is a high-purity collagen renowned for its excellent biocompatibility, biodegradability, and cell adhesion properties. Widely used in life sciences and biomedical research, it's often dubbed a "universal tool" in the lab—especially as the perfect "adhesive" for two-dimensional cell culture.
The core function of Type I rat tail collagen is to replicate the cell's natural "home"—the ECM—helping cells stably adhere to culture surfaces while maintaining normal morphology. Its mechanism for promoting cell attachment and survival hinges on several key factors:
(i) Providing Adhesion Recognition Sites: Type I collagen molecules contain RGD (Arginine-Glycine-Aspartic acid) sequences that are specifically recognized and bound by integrins on the cell membrane, facilitating cell spreading and anchoring¹.
(ii) Divalent Cation-Assisted Anchoring: Mg²⁺ and Ca²⁺ are essential for cell binding to native collagen. Appropriately supplementing Mg²⁺ during collagen dilution and coating effectively enhances cell adhesion efficiency².
For difficult-to-attach cells on conventional cultureware—such as hepatocytes, NPCs, intestine epithelial cells—Type I collagen coating dramatically improves their attachment and growth.
But while the collagen foundation is basic, the application is anything but.
Traditional on-site Type I collagen coating is tedious, requiring multiple steps: dilution, coating, incubation, and washing—a laborious, time-consuming process!
MileCell introduces the Pre-Coated Type I Rat Tail Collagen Culture Plate, featuring sterilized collagen that is pre-coated, dried, and vacuum-sealed. Ready to use right out of the bag, it dramatically simplifies your workflow. Key advantages include:
Instant Use: Compresses 45 minutes of "coating operation" into a 1-second "lid-lift"!
Vacuum Sterility: Shipped in a "vacuum-transparent" jacket to ensure complete sterility.
Reliable Hepatocyte Attachment: When pitted against traditional on-site coated plates, the pre-coated version delivers fully comparable adhesion rates—cells lie flat and stable√, with no difference in growth status.
Long-Term Storage: Your long-term experimental partner—if the plate remains unopened, the collagen stays "frozen in time," perfect for extended research needs.
Hepatocyte culture no longer means "time-consuming coating"—pre-coated plates make it effortless! Save time, save effort, ensure stable adhesion: the efficient new choice for your laboratory.
| Cat. No. | Product Description | Size |
| CoI-Coated-6w | Collagen I Coated 6-well Plate | 1 Plate |
| CoI-Coated-12w | Collagen I Coated 12-well Plate | 1 Plate |
| CoI-Coated-48w | Collagen I Coated 48-well Plate | 1 Plate |
| CoI-Coated-96w | Collagen I Coated 96-well Plate | 1 Plate |
| CoI-Coated-384w | Collagen I Coated 384-well Plate | 1 Plate |
