2024.09.30
Product Introduction
Intestinal subcellular fractions as a test system is highly recommended due to the importance of intestinal enzymes in the first-pass metabolism of orally ingested xenobiotics. Consequences of intestinal biotransformation can be very significant, including toxification by bioactivation and detoxification by aiding in excretion.
Product Features
▪ Large lots derived from pooled male or female donors of animal liver subcellular fractions to minimize lot-to-lot variation and ensure long-term availability.
▪ Provide intestinal subcellular fractions from four toxicologically significant species: Cynomolgus Monkey, Beagle Dog, Sprague-Dawley Rat and CD-1 Mouse.
▪ PMSF-free intestine products are prepared using the same method as regular intestine products but do not include PMSF in the buffer.
Product Information
Catalog No. | Product Discription | Size |
IMCY-100P-P | Pooled Male Cynomolgus Monkey Intestine Microsomes, PMSF | 0.5mL x 20mg/mL |
IMCY-100P-NP | Pooled Male Cynomolgus Monkey Intestine Microsomes, PMSF free | 0.5mL x 20mg/mL |
IMRM-100P-P | Pooled Male Rhesus monkey Intestine Microsomes, PMSF | 0.5mL x 20mg/mL |
IMRM-100P-NP | Pooled Male Rhesus monkey Intestine Microsomes, PMSF free | 0.5mL x 20mg/mL |
IMBD-100P-P | Pooled Male Beagle Dog Intestine Microsomes, PMSF | 0.5mL x 20mg/mL |
IMBD-100P-NP | Pooled Male Beagle Dog Intestine Microsomes, PMSF free | 0.5mL x 20mg/mL |
IMSD-100P-P | Pooled Male SD Rat Intestine Microsomes, PMSF | 0.5mL x 20mg/mL |
IMSD-100P-NP | Pooled Male SD Rat Intestine Microsomes, PMSF free | 0.5mL x 20mg/mL |
IMCD-100P-P | Pooled Male CD-1 Mouse Intestine Microsomes, PMSF | 0.5mL x 20mg/mL |
IMCD-100P-NP | Pooled Male CD-1 Mouse Mouse Intestine Microsomes, PMSF free | 0.5mL x 20mg/mL |
Metabolic Stability
A. Monkey Intestine Micrsomes, no PMSF B. Monkey Intestine Micrsomes, with PMSF
Figure 11 Cynomolgus Monkey Intestine Micrsomes no PMSF and with PMSF of MileCell Bio have higher clearance rates for Midazolam, Raloxifenel, Nicardipine hydrochloride(NIC) and 7-hydroxycoumarin(7-HC) compared to competitive brand.
