2024.05.06
Title: "Unveiling Superior Rodent Hepatocyte Primary Cell Products"
Subtitle: "Milecell Bio Launches Flagship Products: CD-1® (ICR) IGS and C57BL/6N Mouse Primary Hepatocytes, Elevating In Vitro Screening Models for Pharmaceutical Research"
Rodent primary hepatocytes, directly isolated from the liver, possess unique advantages, maintaining physiological relevance to in vivo conditions for studying drug metabolism and toxicity. By utilizing these cells in vitro, ethical concerns associated with animal experiments are mitigated while costs are reduced. Primary hepatocytes have diverse applications in molecular biology, cell biology, and biomedical research, including drug screening, metabolism studies, and toxicology research.
CD-1 and C57BL/6 mice are prevalent experimental models, each offering distinct physiological characteristics. Therefore, developing primary liver cells from these strains is essential for liver disease modeling and drug development. To meet this demand, we introduce our flagship product: primary liver cells from small animals, demonstrating our commitment to liver cell research and drug development.
Figure1. Qualification of Milecell High-Quality Mouse CD-1 Cryoplateable Hepatocytes for Sustained Monolayer Culture over 48 Hours
Quality Assurance: Our rodent primary hepatocytes undergo rigorous screening and testing to ensure unparalleled quality and reliability, adhering strictly to industry standards. We provide large batches of cryopreserved cells with excellent attachment performance, suitable for various applications such as 3D liver spheroid construction.
Versatile Applications: Our hepatocyte cells demonstrate high versatility, excelling in drug metabolism studies, toxicity screening, and disease modeling.
Performance Optimization: Our rodent primary hepatocytes undergo production optimization processes, exhibiting outstanding metabolic activity, physiological relevance, and long-term viability, ensuring accurate experimental results.
OEM and Customized Production: We offer customized solutions tailored to specific research needs, from cell isolation protocols to specialized culture medium formulations.
Scientific Support: With an experienced team, we provide comprehensive scientific support to ensure experiment success. Milecell rigorously inspects and validates the quality of its mouse primary hepatocytes, ensuring compliance with regulatory standards.
In addition to CD-1 and C57BL/6 mice, we offer primary hepatocytes from various species, tested for quality and safety.
Summary:
The disparities in characteristics, genetic background, metabolic activity, and sensitivity to hepatotoxicity between C57BL/6N Mice and CD1 IGS guide researchers in refining experimental designs for specific research objectives (please refer/see the table below). While both C57BL/6 and CD-1 mouse hepatocytes serve as general-purpose liver cell models for research applications, including drug safety and efficacy testing, they each offer distinct advantages in various areas. C57BL/6 hepatocytes are well-suited for metabolic studies and disease modeling, particularly concerning liver diseases like NAFLD, whereas CD-1 hepatocytes excel in high-throughput screening assays for drug metabolism, cytotoxicity, and efficacy evaluation. Comparative studies using both strains unveil species-specific disparities in drug metabolism and toxicity, enhancing the predictability of toxicological assessments during drug development.
Table1: Comparative Characteristics of C57BL/6N and CD-1® (ICR) IGS Mice
| Catalog Number | Discription | Size |
| CMH-100CB-SQ | Cryopreserved Male C57BL/6 Mouse Hepatocytes (Pooled, Suspension & Metabolism Qualified) | 5 million/vial |
| CMH-100CBP-PQ | Cryopreserved Male C57BL/6 Mouse Hepatocytes (Pooled, Plateable Qualified) | 5 million/vial |
| CMH-100CD-SQ | Cryopreserved Male CD-1 Mouse Hepatocytes (Pooled, Suspension & Metabolism Qualified) | 5 million/vial |
| CMH-100CDP-PQ | Cryopreserved Male CD-1 Mouse Hepatocytes (Pooled, Plateable Qualified) | 5 million/vial |
Table2: Mouse Hepatocyte Product List
