2024.06.17
Comprehensive Solutions for Preclinical Research:
MileCell Bio Company's Cynomolgus Monkey Hepatocyte Product Line
Primary hepatocytes are essential for studying drug absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox), as they closely mimic liver functions in vitro. Cynomolgus monkey hepatocytes, due to their genetic and physiological similarity to humans, offer unique benefits for preclinical drug research.
Advantages
High Physiological Relevance: Cynomolgus monkeys share significant genetic and physiological similarities with humans, ensuring an accurate reflection of human liver functions.
Stability and Reproducibility: Optimized for consistent growth and function, these hepatocytes ensure reliable and reproducible experimental results.
Strong Metabolic Capability: Retaining key enzyme systems like CYP450, these cells provide drug metabolism pathways and rates similar to those in humans.
Accurate Toxicity Prediction: High similarity to human hepatocytes allows for reliable prediction of potential liver toxicity in humans.
Applications
Drug Metabolism Studies: Detailed investigation of drug metabolism pathways and rates, aiding in dosage design and optimization.
Drug-Drug Interaction Studies: Evaluation of interactions between drugs, preventing adverse reactions in clinical trials.
Toxicity Assessment: Early identification of potential liver toxicity, reducing risks and costs in drug development.
Drug Screening and Optimization: High-throughput screening for metabolic and toxicological properties of new drug candidates, facilitating drug optimization.
Targeted Delivery: ASGPR's predominant expression in cynomolgus monkey hepatocytes makes it an excellent target for delivering therapeutic agents to liver cells. This specificity is crucial for small nucleic acid drugs like siRNA and antisense oligonucleotides, providing a valuable platform for evaluating therapeutic efficacy and potential toxicity.
MileCell Bio Cynomolgus Monkey Primary Hepatocyte Products:
MileCell Bio Company's cynomolgus monkey primary hepatocyte model, known for its high physiological relevance, stability, and strong metabolic capabilities, is a crucial tool in preclinical drug research. MileCell Bio cryopreserved cynomolgus hepatocytes are pre-qualified to ensure high cell viability and efficient cell attachment post-thawing. Additionally, these hepatocytes exhibit robust metabolic enzyme activities, making them ideal for a wide range of applications, including drug metabolism studies, toxicity assessment, drug interaction research, and high-throughput drug screening and optimization.
*MileCell Bio Company's cynomolgus monkey primary hepatocyte models are pre-qualified and available in both pooled donor batches for suspension hepatocyte grade and single donor batches for plateable hepatocyte grade.
See the company's cynomolgus monkey primary hepatocyte, Microsomes and S9 product list above.
