2024.06.02
Superior Cryopreserved Beagle Dog Hepatocytes: MIleCell Bio's Top-Quality Products for Advanced Research
The utilization of primary hepatocytes from various species, including Beagle dogs, is vital in in vitro ADME/Tox studies for understanding species-specific metabolic pathways, enzyme expression levels, and anticipating human drug responses. Beagle dog hepatocytes are particularly valuable in preclinical drug investigations, being crucial for exploring drug-induced cholestasis, hepatotoxicity, and discerning unique metabolites absent in rodent models. Integrating in vitro data from Beagle dog hepatocytes with in vivo observations enhances the predictive capacity of preclinical studies and supports superior clinical trial design, aligning with the 3Rs principles by potentially reducing the need for animals in in vivo experiments.
Cross-species comparisons aid in selecting the most suitable animal models and furnishing comprehensive safety evaluations. Beagle dog hepatocytes, with their physiological and metabolic resemblances to humans, are vital assets for investigating drug-induced cholestasis, offering early indications of potential human toxicity. Notably, they exhibit distinctive cytochrome P450 enzyme profiles, phase II metabolism patterns, bile acid compositions, and transporter protein activities compared to rodent counterparts, providing a more precise portrayal of human drug metabolism and toxicity in preclinical drug research and development.
MileCell Bio: Your Trusted Source for High-Quality Cryopreserved Beagle Dog Hepatocytes
At MileCell Bio, we offer a comprehensive range of cryopreserved Beagle dog hepatocytes tailored to meet your research needs. Our product lineup includes both pooled hepatocytes in suspension from multiple donors and cryoplateable qualified hepatocytes from single donors. These hepatocyte products undergo stringent characterization processes to ensure superior quality.
Confidence and Quality: With MileCell Bio, you can trust that you're receiving hepatocytes of the highest standard. Our cryopreserved hepatocytes provide convenience and flexibility in study design, allowing for experiments tailored to your specific requirements and timelines.
Reproducibility and Reliability: Our large pooled lot sizes ensure reproducible experimental data, minimizing variability and enhancing the reliability of your research outcomes, ensuring consistency across studies.
Comprehensive Characterization: Our primary hepatocytes are fully characterized by their high quality. We meticulously evaluate cell viability, metabolic activity, and cell attachment efficiency, guaranteeing reliable and reproducible results in your experiments.
Ease of Use: Designed for ease of use and cost-effectiveness, our pooled Beagle dog hepatocytes facilitate multiple donor studies within the same experiment, streamlining workflows and maximizing efficiency in your research endeavors.
Cryopreserved Dog Hepatocytes from MileCell Bio: Optimal Solutions for Long-Term and Short-Term Preclinical Studies
Dog hepatocytes from MileCell Bio are cryopreserved on the same day they are isolated. These cryoplateable dog hepatocytes are suitable for long-term studies (≥4 hours) such as induction, toxicity, and transport experiments (Figure 2A, 2B). On the other hand, cryopreserved pooled Beagle dog hepatocytes in suspension are primarily used for assessing compound stability and metabolite formation (Figure 2C). These extensive pooled suspension lots are perfect for short-term studies (4-6 hours). This test system is user-friendly and highly valuable for in vitro preclinical research.
Qualification of MileCell Bio High-Quality Cryopreserved Beagle Dog Hepatocytes:
Cryo-plateable lot for long-term study and Pooled suspension lots for short-term studies
Trust MileCell Bio for top-notch hepatocytes, enabling you to conduct your research with confidence and precision. Our cryopreserved Beagle dog hepatocyte products are now available and listed in the table below:
| Catalog Number | Discription | Size |
Suspension Hepatocytes | ||
| CDH-100BE-SQ | Cryopreserved Male Beagle dog Hepatocytes (Pooled, Suspension & Metabolism Qualified) | 5 million/vial |
| Plateable Hepatocytes | ||
| CDH-100BES-PQ | Cryopreserved Male Beagle dog Hepatocytes (Single, Plateable Qualified) | 5 million/vial |
| CDH-100BEP-PQ | Cryopreserved Male Beagle dog Hepatocytes (Pooled, Plateable Qualified) | 5 million/vial |
